Description
Choline alfoscerate reaches the bench under at least half a dozen names, and the label of a 1 g unit compresses a lot of analytical information into a few lines. The glossary below unpacks each entry in the order it usually appears on a certificate of analysis. See also our laboratory reagent: L-DOPA ≥ 99%. Pure chemical substance without fill.
- Registry number
- 28319-77-9. This is the identifier to quote in orders, in the reagent register and on waste documentation; the many synonyms in circulation are not interchangeable identifiers.
- Molecular formula
- C8H20NO6P. The molecule has no strong chromophore, so quantification rarely rests on simple ultraviolet chromatography.
- Molecular weight
- 257.22. Used to convert a weighed mass into a molar concentration; recalculate if the certificate reports a salt or a hydrate.
- Systematic identity
- The glycerophosphate ester of choline, indexed as choline alfoscerate, glycerophosphocholine and L-alpha-glycerylphosphorylcholine. All refer to the same compound; only the registry number ties them together in a database search.
- Chirality
- The natural form carries the L configuration at the glycerol centre. A racemic lot is a different article and has to be ordered and documented as such, because a chiral method will resolve the two and the assay will not agree.
- Assay
- The percentage figure and, immediately after it, the method that produced it. Without the method the number cannot be compared between two suppliers.
- Water content
- Determined by Karl Fischer titration and reported as a separate line. For a polar compound of this class it is the single parameter most likely to explain a mass balance that refuses to close.
- Residual solvents
- Determined by headspace gas chromatography against the solvent list of the actual manufacturing route, not against a generic table copied from another product.
- Appearance
- Recorded at intake and again at each opening. A change from the described appearance is a documentation event, whatever the certificate says.
- Retest date
- The date after which the stated values are no longer supported by the supplier, valid only under the storage conditions written next to it.
- Container and closure
- Part of the specification, not packaging trivia: a material whose water content is a release parameter depends on the closure.
Two entries carry most of the practical weight. The first is water content, because a polar glycerophosphate weighed in an open room can gain mass while it sits on the balance, which quietly shifts every concentration calculated from that weighing. The remedy is procedural: weigh in a dry atmosphere, keep the exposure short, and treat a drifting weighing as void.
The second is the chirality line. Two lots with identical registry numbers on the invoice can still differ in configuration if one supplier ships a racemic synthetic grade, and a chiral column will show that difference immediately while a routine assay will not. See also our catalogue listing: FL-MODAFINIL, 99% Czystości, 1000MG OR 1GRAM.
Everything else is read once at intake and then archived. A chromatogram kept apart from its certificate loses the batch number that makes it evidence.
Related reagents
- FL-MODAFINIL, 99% Czystości, 1000MG OR 1GRAM
- L-DOPA ≥ 99%. Pure chemical substance without fillers!
- CDP cholina ≥ 99%, 1000mg
- Pramiracetam czystość substancji ≥ 99% 1000mg.
Selected literature
Animal and in vitro studies indexed in PubMed; no human-use guidance is provided here.
- Kolykhalov IV [Clinical and immunological effects of choline alfoscerate in the treatment of amnestic type Mild Cognitive Impairment] 2022, Zhurnal nevrologii i psikhiatrii imeni S.S. . PMID 36412158
- Sun L Validated quantitative (31)P NMR spectroscopy for positional isomeric impurity determination in L-α-glycerylphosphorylcholine (L-α-GPC) 2022, Journal of pharmaceutical and biomedical ana. PMID 36179504
- Lee HJ Potential Risk of Choline Alfoscerate on Isoflurane-Induced Toxicity in Primary Human Astrocytes 2024, Journal of Korean Neurosurgical Society. PMID 37859347
- Lee SH Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment 2017, Brain research. PMID 27765578
Material status. The material is not intended for human use. Beyond human use, animal use is also excluded. The material serves solely as a standard and reagent in HPLC and GC-MS analysis. It is neither a medicinal product nor a foodstuff.
