Description
Palmitoylethanolamide is the amide formed from palmitic acid and ethanolamine, catalogued under CAS 544-31-0 with the formula C18H37NO2 and a molar mass of 299.5 g/mol. It belongs to the N-acylethanolamine family, which explains both its poor water solubility and the specific hydrolysis products a laboratory looks for. The sequence below is the order in which a newly delivered gram is handled. See also our catalogue listing: VIAGRA / Tadalafil Czystość ≥ 99% 1000mg..
Sequence for a newly received lot
- Compare the pouch label, batch number and declared net mass against the delivery note before the seal is broken.
- File the certificate of analysis under the batch number and photograph the intact packaging.
- Let the container equilibrate to room temperature, then open it in a dry area away from air currents.
- Take a representative portion for identity work: infrared spectrum and chromatographic retention compared with a standard.
- Run the assay and the related-substance separation, recording which detector produced each figure.
- Determine water content, and residual solvents if the certificate is silent about them.
- Sub-aliquot into amber vials, each labelled with the batch number and the date of division.
- Enter the lot into the register with received mass, aliquot count and retest date, and only then release it for work.
Steps four and five sit in that order deliberately. Identity is cheap and fast; an assay run on a misidentified solid wastes a column equilibration and, worse, produces a number that looks credible in a notebook.
Notes on the verification steps
The compound has no useful ultraviolet chromophore, so quantitation runs on charged aerosol or evaporative light scattering detection after reversed-phase separation, on flame ionisation detection in gas chromatography after silylation, or on tandem mass spectrometry when trace sensitivity is needed. Whichever route is chosen, the certificate should say so, since the three approaches respond differently to the impurities present. See also our catalogue listing: Mebicar / Mebicar / Temgicoluril – 30x capsules 10.
The related substances worth naming are the hydrolysis pair, free palmitic acid and ethanolamine, and the homologous amides carried in from the fatty acid feedstock, chiefly the stearoyl and oleoyl analogues. Homologues differ from the main compound by a small increment of chain length and elute close to it, so a shallow gradient and a long column are worth the extra run time.
Storage and release
Store the sub-aliquots dry, closed and protected from light, at the temperature stated on the certificate, and keep the unopened remainder as the reserve sample for any later query. Release for work means an entry in the register, not merely a vial on a shelf; the entry links mass consumed to a batch number, and that link is what makes a later investigation possible at all.
See also
- Mebicar / Mebicar / Temgicoluril – 30x capsules 100mg. Purity ≥ 99%
- VIAGRA / Tadalafil Czystość ≥ 99% 1000mg.
- ALCAR / Acetylo-L-Karnityna – Czystość ≥ 99% masa netto 1000mg.
- Aniracetam ≥ 99%. Czysta substancja chemiczna bez wypełniaczy 1000mg.
Indexed publications
Animal and in vitro studies indexed in PubMed; no human-use guidance is provided here.
- Wang Y Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects 2025, Drug design, development and therapy. PMID 40827226
- Assogna M Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders 2022, Biomolecules. PMID 36009055
- Lama A Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice 2022, Brain, behavior, and immunity. PMID 35176443
- Valenza M Palmitoylethanolamide and White Matter Lesions: Evidence for Therapeutic Implications 2022, Biomolecules. PMID 36139030
Handling qualification. Human use is outside the scope of this product. No veterinary applications are provided for. This is a high-purity laboratory reagent intended for analytical work by HPLC and GC-MS. It is not a drug, supplement or food.
