Description
| Parameter | Value |
|---|---|
| Substance | L-tyrosine, proteinogenic amino acid, synthetic material |
| CAS registry number | 60-18-4 |
| Summary formula | C9H11NO3 |
| Formula weight | 181.19 |
| Configuration | L, single stereocentre in the side chain |
| Appearance | White crystalline powder |
| Declared assay | Not less than 99 percent of the main component |
| Net mass | 1000 mg per sealed unit |
| Solubility character | Sparingly soluble in water, dissolves in dilute acid and in alkali |
| Water content | By Karl Fischer titration or loss on drying, per batch |
| Sulfated ash | Determined per batch and stated on the certificate |
| Storage | Cool, dry, sealed, protected from light |
What the phenol group changes for the analyst
Among the standard amino acids this one carries a phenolic hydroxyl on an aromatic ring, and that single structural detail governs most of the analytical work. The ring gives a genuine ultraviolet chromophore, so direct detection is possible where aliphatic amino acids demand derivatisation. The same hydroxyl makes the molecule susceptible to oxidation, which is why discoloured material is held rather than used.
Assay routes and their limits
Classical ion-exchange separation with post-column ninhydrin detection remains the reference approach for amino acid material and copes well with a crystalline solid of this kind. Reversed-phase liquid chromatography with ultraviolet detection is faster and takes advantage of the aromatic ring directly. Non-aqueous acid-base titration gives a total figure for the amino acid function but says nothing about which amino acid is present, so it never closes identity on its own. See also our catalogue listing: ALCAR / Acetyl-L-Carnitine – Purity ≥ 99% net weig.
Chemical purity against optical purity
These two properties are measured separately and confusing them is the commonest error on a receiving bench. Chemical assay answers how much of the sample is tyrosine in any configuration; optical purity answers how much of that tyrosine is the L form. The second requires either a chiral stationary phase or a polarimetric determination under defined conditions, and the result belongs on the batch certificate.
- Confirm the registry number on the inner label against the certificate header
- Record an infrared spectrum and compare it with a retained reference trace
- Run the assay by a method the certificate actually names
- Request optical purity explicitly when the application depends on configuration
- Log water content and sulfated ash as parameters separate from the assay
Handling, dissolution and storage
Because the solid is poorly soluble in neutral water, stock solutions are usually made in dilute hydrochloric acid or dilute alkali and then adjusted, and the preparation route is recorded with the solution. Warming to force dissolution risks degradation of the phenolic ring and is a poor substitute for pH adjustment. The sealed container is kept cool, dry and dark, brought to room temperature before opening, and every withdrawal is entered in the substance ledger. See also our laboratory reagent: Mebicar / Mebicar / Temgicoluril – 30x capsules 10.
Related reagents
- Mebicar / Mebicar / Temgicoluril – 30x capsules 100mg. Purity ≥ 99%
- ALCAR / Acetyl-L-Carnitine – Purity ≥ 99% net weight 1000mg.
- Fenyloalanina / L-Phenylalanine ≥ 99% 1000mg
- Methylene Blue / BŁĘKIT METYLENOWY. Czystość ≥ 99.50% 1000mg.
References
Animal and in vitro studies indexed in PubMed; no human-use guidance is provided here.
- Mazzocco MM Cognition and tyrosine supplementation among school-aged children with phenylketonuria 1992, American journal of diseases of children (19. PMID 1415060
- Solon-Júnior LJF The effect of tyrosine supplementation on whole-body endurance performance in physically active population: A systematic review and meta-analysis including GRADE qualification 2023, Journal of sports sciences. PMID 38290812
- Jongkees BJ Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands–A review 2015, Journal of psychiatric research. PMID 26424423
Reagent classification. The material is not intended for human use. It is not a veterinary product either. This is a high-purity laboratory reagent intended for analytical work by HPLC and GC-MS. It is not a drug, supplement or food.
